iS Clinical

iS Clinical is a famous skincare brand created by the American company Innovative Skincare, founded in 2002 by biochemists Bryan Johns and Alex Cole.  

The brand’s concept emerged after research revealed that 85% of products from leading cosmetic brands did not match their stated ingredients. This prompted the founders to create a line with absolute formula transparency and pharmaceutical-grade ingredient purity.  

Today, the brand’s mission is to enhance physical and emotional well-being through science-backed skincare.  

iS Clinical covers all skincare categories. The brand excels particularly in treating complex conditions (acne, rosacea, hyperpigmentation) and delivering clinically proven anti-aging solutions.  

The brand avoids unnecessarily large product ranges, focusing on multifunctionality: a single product addresses 3–5 concerns.  

All products undergo independent clinical trials on final formulations, not individual components.  

iS Clinical cosmeceuticals are produced under the highest ethical standards. The brand is cruelty-free and utilizes recyclable packaging along with environmentally responsible ingredient sourcing.  

Unique Technologies and Ingredients  

Extremozymes® – iS Clinical’s revolutionary innovation. These enzymes are derived from plants surviving in extreme environments. Their ability to protect cells in harsh conditions is harnessed in products that repair skin DNA and neutralize damage from UV radiation, pollution, and stress.  

Multitasking formulas is another hallmark of the brand. By combining high concentrations of active ingredients (e.g., L-ascorbic acid, salicylic acid, botanical extracts), iS Clinical creates products that address multiple concerns simultaneously.  

4 Steps to Healthy Skin with iS Clinical  

The brand structures skincare rituals around four key steps (Cleanse → Treat → Hydrate → Protect), emphasizing their synergy. These are science-backed "tools" for skin transformation, designed not to mask imperfections but to drive long-term cellular-level changes.  

1. Cleanse  

iS Clinical’s Cleanse line transforms basic washing into a therapeutic act, combining impurity removal with bioactive skin preparation for subsequent steps.  

Instead of harsh scrubs, it uses a duo of plant enzymes and controlled-release acids to gently dissolve dead cells without disrupting the hydrolipidic barrier.  

Stabilized antioxidants in phospholipid capsules—vitamins C and E—work even when exposed to water, neutralizing free radicals from UV radiation and urban smog.  

Extracts of healing plants like Centella asiatica and Camellia sinensis soothe redness while reducing oxidative stress, creating an "antioxidant shield."  

The products intelligently balance skin pH to an optimal 4.5–5.0, enhancing penetration of treatment serums by 30% and preventing post-inflammatory hyperpigmentation.  

In professional practice, these products serve as bases for peels and device-based treatments.

2. Treat  

The Treatment line is central to iS Clinical’s 4-step system. It targets specific skin concerns using high concentrations of pharmaceutical-grade active ingredients.  

Products in this category address the root mechanisms of aging and inflammation.  

They are multitasking: e.g., one serum can simultaneously reduce pigmentation, stimulate collagen synthesis, and counteract environmental stress — validated by clinical trials on final formulations.  

The core goal is transformation, not masking. The products reprogram cellular behavior to:  

• Brighten dark spots,  
• Suppress P. acnes bacteria in acne,  
• Increase dermal density.  

Each formula employs "smart delivery" systems. Liposomal capsules protect unstable molecules (e.g., vitamin C), while proprietary technologies like Extremozymes® (enzymes from extremophile plants) enhance skin’s natural DNA repair and environmental adaptation. Formulas remain safe for sensitive skin, free of parabens, sulfates, and synthetic fragrances.  

This step maximizes efficacy in synergy with other iS Clinical steps: cleansing enhances ingredient penetration, while subsequent hydration locks in results and restores barrier function.  

3. Hydrate  

The Hydrate step employs a strategy that restores the skin’s lipid barrier by stimulating ceramide and fatty acid synthesis — fundamentally different from occlusive "sealing" methods.  

• Hydrating products act as bioregulators to:  
• Moisturize,  
• Counteract oxidative stress,  
• Increase skin density,  
• Boost natural collagen,  
• Rebalance the skin microbiome.  

4. Protect  

The Protect line is not merely a UV barrier but a comprehensive skin defense ecosystem, merging sun protection with bioactive care. It is the only SPF line certified for post-laser procedures, accelerating healing by combining physical protection with anti-inflammatory action.  

Its formulas follow an "intelligent shield" principle:  

• physical filters (zinc, titanium dioxide) reflect broad-spectrum radiation,  
• biomimetic adaptogens (Extremozymes®) neutralize infrared damage and environmental aggressors.  

The products function as a "second immune system": antioxidant blends (vitamins C+E, Centella extract) quench free radicals from pollution, while peptides stimulate DNA repair to reduce photoaging risks.  

Light textures prevent white cast or stickiness, providing matte finish without overdrying—even for oily or acne-prone skin.  

Crucially, protection is preemptive: stabilized actives create an adaptive layer that responds to humidity, temperature, and pollution, maintaining efficacy for up to 8 hours.  

Clinically proven: regular use reduces hyperpigmentation risk by 78% and increases epidermal density by 33%, doubling as anti-aging therapy.  

iS Clinical Skincare Sets  

iS Clinical sets are curated solutions for specific skin concerns, combining products from multiple steps (Cleanse, Treat, Hydrate, Protect) into unified systems.  

The brand avoids random combinations. Each set is a deliberate protocol where products enhance each other’s efficacy—validated by research. This transforms routines into controlled therapies, not disjointed steps.  

Sets address scenarios like:  

• Post-procedure recovery (e.g., post-laser or peel),  
• At-home "intensive therapy" to maintain results after professional treatments,  
• Chronic issues (acne, rosacea).  

Sets mitigate risks by:  

• Excluding incompatible combinations (e.g., retinol + acids),  
• Offering 15–20% savings versus individual purchases. For newcomers, they provide affordable brand testing.  
• Pre-designed routines eliminate the need to study each product’s composition, with step-by-step usage guides.  

iS Clinical products are available at Milfey online cosmetics store. We guarantee 100% authenticity, high quality and competitive prices as we work exclusively with official brand distributors. Order professional clinically proven skincare online with delivery across Europe!